They are different species (and different genuses). Domestic rabbits are descended from the wild European rabbit, genus Oryctolagus. Native North American leporids are all genus Sylvilagus (cottontails) or genus Lepus (jackrabbits and hares). So domestic and wild European rabbits may interbreed...
You did such a great job highlighting the uses of American Blues. Maybe add a brief description for the San Juans as well? "This is a small breed, suitable for..." or something to that effect.
Now that the weather is starting to warm up, I would like to start taking my pet rabbit outside a few times a week for some additional exercise and mental stimulation. I was thinking that the easiest way to achieve this would be to let her have some (supervised) play time in the chicken run...