It will depend on how quick the first treatment was from when they got it, and if the eyes are still runny. If there is no noticeable wetness or runniness from the eyes, then no they will not lose all the cloudiness. Also what are you treating them with? The standard treatment has been LA 200 or 300 shots sq in the neck and possible eye treatment. We use mastitis medicine, like today or tomorrow or one that has pennicillin in it that you would use up the quarter. It doesn't hurt the eye, will coat it with the semi-liquid medicine and soothe it as well as treat the infection. Use about 1/5th or so of the tube, just under the eyelid so it goes directly on the eyeball. Several farmers here are now using Draxxin which is expensive but they say really works. We have a couple of cases of real bad pinkeye that hasn't responded to everything else so that is my next step. We also cover with an eye patch which they will rub off in a few days. I cut up an old pair of soft bluejeans and use the glue they sell at the feed store to put on heat detector patches; alot cheaper than the "shut eye" brand you buy. Just take the tube of glue, put a thin patch around the eye then stick the jean material on the glue -- after you have treated the eye.